SARS-CoV-2 Stool Analysis – Screening and Surveillance Test

SARS-CoV-2 Stool Analysis – Screening and Surveillance Test

Coronavirus disease 2019 (COVID-19) is a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

SARS-CoV-2 can be detected in stool with the Real Time quantitative polymerase chain reaction (RT-PCR) method. A positive result can indicate actual infection with SARS-CoV-2, at the time of collection.

SARS-CoV-2 can be detected in stool for typically about 1-2 days before COVID-19 symptoms present and many days after the symptoms have disappeared.

The SARS-COV-2 Stool Test is Helpful for the Following Individuals:

  • Patients exhibiting signs and symptoms of SARS-CoV-2, including:
    • Fever
    • Cough
    • Shortness of breath
    • Gastrointestinal Complaints
  • Asymptomatic Patients Concerned about Having or Transmitting the Virus
  • Surveillance of patients who previously tested positive for COVID-19 by respiratory sample

The SARS-CoV-2 Stool Analysis is not diagnostic of COVID-19. COVID-19 disease can only be diagnosed with positive SARS-CoV-2 results on a respiratory sample.

Key Points
Cutting-edge viral RNA-PCR stool test measures levels of SARS-CoV-2, the virus that causes COVID-19.
Screen, monitor, or prevent transmission in patients at risk for COVID-19.

SARS-CoV-2 in the stool may be found in up to 53.4% of COVID-19 patients.

The virus may be detected in the stool for a period of days to weeks after the initial infection.
Intestinal viral infection may play an important role in COVID-19 disease progression and may increase the risk of more severe disease.
Detection of SARS-CoV-2 in the stool could be used to prevent fecal-oral transmission.

A Direct Link Between COVID-19 and Gastrointestinal Illness
SARS-CoV-2 gains entry into the host via the ACE2 protein, which is found not only in lung epithelia, but also guts epithelia. Therefore, the gut could present an entryway into the host and maybe a site of viral infection.

Indeed, two to eighteen percent of patients with COVID-19 had diarrhea, abdominal pain, and vomiting.7-8 Ten percent of patients presented with diarrhea and nausea one to two days before they developed a fever and respiratory symptoms.

And in some cases, digestive symptoms were the primary symptom of COVID-19.7 Further, GI symptoms with COVID-19 may indicate a more severe course of illness. For example, abdominal pain was reported more frequently in patients admitted to the intensive care unit. SARS-CoV-2 can also be detected in fecal specimens of asymptomatic patients.

Practical

Category
Infection

Sample type
Stool

Average processing time :
3-4 days

 

Research

Prolonged Presence of SARS-CoV-2 Viral RNA in Faecal Samples”, last modified March 19, 2020, accessed March 30, 2020.

Wu Y, Guo C, Tang L, et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The lancet Gastroenterology & hepatology. 2020.

Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020.

Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. Jama. 2020.

Zhang J, Wang S, Xue Y. Fecal specimen diagnosis 2019 novel coronavirus-infected pneumonia. Journal of medical virology. 2020.

Xie C, Jiang L, Huang G, et al. Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests. Int J Infect Dis. 2020;93:264-267.

Tang A, Tong ZD, Wang HL, et al. Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China. Emerg Infect Dis. 2020;26(6).

Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? The lancet Gastroenterology & hepatology. 2020;5(4):335-337.

Pan L, Mu M, Yang P. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. The American journal of gastroenterology. 2020;Preproof.

Yuen KS, Ye ZW, Fung SY, Chan CP, Jin DY. SARS-CoV-2 and COVID-19: The most important research questions. Cell Biosci. 2020;10:40.

Repici A, Maselli R, Colombo M, et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know. Gastrointestinal endoscopy. 2020.

Gao Z, Kang Y, Yu J, Ren L. Human pharyngeal microbiome may play a protective role in respiratory tract infections. Genomics Proteomics Bioinformatics. 2014;12(3):144-150.

Hanada S, Pirzadeh M, Carver KY, Deng JC. Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Front Immunol. 2018;9:2640.

Sample Test Report PDF

Coronavirus Stool Testing PDF

The SARS-CoV-2 stool test also uses RT-PCR technology to detect the presence of SARS-CoV-2 in stool and is now available, on a limited basis, for ordering by practitioners. Coronavirus stool tests can help practitioners screen for SARS-CoV-2 and monitor and surveil patients who’ve tested positive for the disease.

IMPORTANT: SARS-CoV-2 Stool Analysis Must Be Ordered by Contact Form or by Phone at This Time (+34) 622 624 112 SARS-CoV-2 Stool testing is not currently available via our online portal.

We offer free drop shipment of kits directly to patients for qualified tests. This allows them to easily and conveniently collect their specimen at home, and send it back to the lab for immediate processing.

Contact Form

By checking this box I consent to the use of my information provided for communication purposes.*I am over 18 years of age.*